Recent Research Activities
The Center for Excellence in Aging’s Research Core focuses on developing new collaborations across different disciplines in basic and clinical research. The Core’s goal is to translate findings into improved prevention and patient care. Below are examples of recent research activities.
HIV and Aging Religious Orders Study Memory and Aging Project (MAP) Minority Aging Research Study (MARS) Latino CORE Study The PINE Study (Population Study of ChINese Elderly in Chicago) Chicago Health and Aging Project (CHAP) Mediterranean-DASH Intervention From Neurodegenerative Delay (MIND) Diet Intervention Trial Filial Piety Study Dementia and Caregiving Study Depression Intervention Study Suicide Intervention Study Breast and Cervical Cancer Patient Navigation Study Department of Health and Human Services Administration on Aging Elder Abuse Predictive Index Study Taiwan CVD Longitudinal Aging Study GuangXi Centenarian Study Shanghai Aging Study
Religious Orders Study
More than 1,100 older religious clergy (nuns, priests and brothers) have agreed to medical and psychological evaluation each year and brain donation after death. Researchers are using information from the study to discover what changes in the brain are responsible for memory and movement problems. The study also looks closely at the transition from normal functioning of the aging brain to the mild cognitive impairment that can be an early sign of Alzheimer’s disease.
Principal investigator(s): David Bennett, MD; Funding agency: National Institutes of Health Dates of grant/study: 1994 to 2016
Memory and Aging Project (MAP)/Epidemiologic Study of Neural Reserve and Neurobiology of Aging
Study design involves a detailed assessment of risk factors for AD in older persons without known dementia who agree to annual clinical evaluation and organ donation at the time of death. “By participating in the Memory and Aging Project, you join us in our efforts to better understand, treat and hopefully prevent these problems associated with abnormal aging. Study participants must agree to yearly testing and organ donation, since Alzheimer’s disease can be best documented by examining brain tissue under a microscope after death.”
Principal investigator(s): David Bennett, MD; Funding agency: National Institute on Aging; Dates of grant/study: 2001 to 2019
Minority Aging Research Study (MARS)/Racial Differences in Late-Life Cognitive Decline and Risk of Alzheimer’s Disease
The Minority Aging Research Study is a unique study designed for older African Americans. The goal is to learn how to prevent common problems associated with aging, including poor memory, slowed walking and weakness. We want to understand why we lose certain abilities as we get older, figure out how to improve these abilities, and discover ways to prevent aging-related problems from affecting our children and grandchildren.
Principal investigator(s): Lisa Barnes, PhD; Funding agency: National Institute of Aging; Dates of grant/study: 2004 to 2021
Latino CORE Study
The goal is to learn about the aging process and the risk factors for Alzheimer’s disease of older Latino adults.
Principal investigator(s): David Bennett, MD; Funding agency: National Institute on Aging; Dates of grant/study: 2015 to 2021
Mediterranean-DASH Intervention From Neurodegenerative Delay (MIND) Diet Intervention Trial
The MIND Diet is combination of Mediterranean and DASH diets, focusing on “brain-healthy food groups.” Although many factors determine who gets Alzheimer’s Disease and who doesn’t, this trial is looking at the effects of this diet in providing more protection from the disease.
Principal investigator(s): Martha Clare Morris, ScD; Funding agency: National Institute on Aging; Dates of grant/study: 2017 to 2020